An OEM medical device manufacturer develops or manufactures medical devices, components or complete systems for another company according to an agreed technical and quality framework. Private label medical device manufacturing generally refers to a commercial model in which a product is supplied for sale under another company's brand. However, in regulated medical device markets, branding arrangements can affect which party legally assumes manufacturer responsibilities.

Extracellular vesicles (EVs) are membrane-bound particles released from cells, including platelets. Exosomes represent a biogenesis-defined subtype of EVs originating through the endosomal pathway. Therefore, a particle population should not automatically be described as “exosomes” based only on particle size or concentration. Current MISEV2023 recommendations favor the broader term extracellular vesicles when specific biogenesis has not been demonstrated.

Orthobiologics are biologically derived materials and preparations used in musculoskeletal and regenerative medicine. Common orthobiologic technologies include platelet-rich plasma (PRP), platelet-rich fibrin (PRF), bone marrow aspirate concentrate (BMAC) and adipose tissue-derived preparations such as stromal vascular fraction (SVF). STR Biotechnologies is a medical device manufacturer focused on point-of-care regenerative medicine and orthobiologic preparation technologies

BMAC preparation efficiency should not be evaluated by cell concentration alone. A highly concentrated final sample does not necessarily indicate that a high proportion of the cells originally present in bone marrow aspirate were recovered. For meaningful BMAC evaluation, total cell yield, cell recovery, final volume, cellular composition and reproducibility should be considered together. Commercial BMAC systems can differ substantially in both the percentage of cells recov

SVF isolation efficiency is not determined by cell concentration alone. A reliable Stromal Vascular Fraction (SVF) preparation should be evaluated using multiple parameters, including total cell yield, cell viability, tissue processing efficiency, cellular composition and reproducibility. Both enzymatic and mechanical isolation methods can produce viable SVF preparations, but their cellular characteristics and processing mechanisms may differ.

Platelet-derived extracellular vesicles (pEVs) are membrane-bound particles released by platelets constitutively and in response to activation. Studying these vesicles requires more than simply detecting nanoscale particles. A scientifically robust extracellular-vesicle workflow typically involves several stages: Platelet Source → Pre-Analytical Control → Platelet Activation → EV Release → Separation → Particle Analysis → Morphological Analysis → Molecular Characterization

Platelets are not only carriers of growth factors. When activated, they release a complex biological secretome that includes soluble proteins, cytokines, growth factors and extracellular vesicles. ExoPrime® is designed around this biological pathway. The system begins with the preparation of platelet-rich plasma (PRP). Platelets within the PRP are then mechanically processed through the ACTIFLUX™ titanium component, followed by transfer into STRakin tubes and a controlled c

LP-PRP vs LR-PRP is an important discussion in regenerative medicine, but leukocyte concentration is only one factor that determines the characteristics of Platelet-Rich Plasma (PRP). What Is LP-PRP? Leukocyte-Poor PRP (LP-PRP) contains a reduced concentration of white blood cells. It is frequently used in intra-articular applications, particularly knee osteoarthritis, where limiting the inflammatory component of the preparation may be desirable. What Is LR-PRP? Leukocyte-Ric

Enzymatic and non-enzymatic SVF isolation represent two fundamentally different approaches to adipose tissue processing. Enzymatic isolation uses enzymes such as collagenase to digest extracellular matrix and release individual cellular populations. Non-enzymatic isolation relies on physical processing methods such as mechanical fractionation, centrifugation, filtration and controlled tissue disruption.

What Is BMAC? Bone Marrow Aspirate Concentrate, commonly known as BMAC, is a point-of-care biologic preparation produced from autologous bone marrow aspirate. Bone marrow contains a heterogeneous mixture that may include: hematopoietic cells, mesenchymal stromal/progenitor cells, platelets, mononuclear cells, cytokines, growth factors, plasma, red blood cells, and other marrow components. Importantly, mesenchymal stromal/progenitor cells represent only a small fraction of the

Major Autohemotherapy (MAH) is one of the most widely performed ozone therapy procedures. During treatment, a patient's blood is collected into a sterile vacuum bottle, mixed with a controlled oxygen-ozone gas mixture, and then reinfused intravenously. The quality of the disposable components used throughout the procedure is essential for maintaining sterility, consistency, and an efficient clinical workflow. A complete MAH disposable set typically includes a sterile vacuum o

Explore groundbreaking PRP, PRF, CGF, and exosome technologies for hair, skin, and joint regeneration. Discover the unsung heroes of cellular therapy.

How the INTRAKIN Tube Works The INTRAKIN Tube is designed to produce Autologous Cytokine-Rich Serum (ACRS) using the patient's own blood. After collecting 20–25 mL of blood, the tube is incubated for 3 hours, allowing interaction between blood cells and the medical-grade glass beads. The sample is then centrifuged, and the cytokine-rich serum is collected for clinical use according to the physician's protocol. Benefits of the INTRAKIN Tube Closed-system design Medical-grade g

PRP Therapy (Platelet-Rich Plasma Therapy) is an innovative regenerative medicine treatment that uses the patient's own blood to promote tissue repair and accelerate healing. By concentrating platelets and growth factors, PRP Therapy enhances the body's natural healing process without the use of synthetic substances. Today, PRP Therapy is widely used in orthopedics, sports medicine, dermatology, aesthetics, and hair restoration. It helps support tissue regeneration, reduce di

Hair loss affects millions of people worldwide, impacting both confidence and quality of life. Platelet-Rich Plasma (PRP) therapy has emerged as a safe, minimally invasive treatment that harnesses the body's natural healing potential to support hair restoration. PRP is prepared by collecting a small sample of the patient's blood and concentrating the platelets using a specialized PRP system. These platelets are rich in growth factors that help stimulate hair follicles, improv

Platelet-Rich Plasma (PRP) has become one of the most widely used regenerative treatments in sports medicine, helping athletes and active individuals recover from sports injuries while supporting the body's natural healing process. PRP is prepared from the patient's own blood by concentrating platelets rich in growth factors such as PDGF, TGF-β, and VEGF. These growth factors promote tissue repair, collagen production, and angiogenesis, making PRP therapy a valuable option fo

The Science Behind PRP Tube Performance When selecting a Platelet-Rich Plasma (PRP) system, many clinicians naturally compare tubes based on their appearance. Similar dimensions, cap colors, labels, and packaging can create the impression that two PRP tubes will perform in exactly the same way. However, appearance alone does not determine performance. Behind every PRP tube lies a combination of engineering, manufacturing precision, material science, and quality control that m

Platelet-Rich Plasma (PRP) has become one of the most widely used regenerative therapies in orthopedics, sports medicine, dermatology, plastic surgery, and aesthetic medicine. While many clinicians focus on centrifugation speed, spin time, or activation protocols, one of the most overlooked factors is the design of the PRP collection tube itself. The quality of PRP begins long before centrifugation starts. The blood collection device plays a critical role in preserving platel

What Is BMAC? Bone Marrow Aspirate Concentrate (BMAC) is an advanced regenerative medicine therapy that utilizes a patient's own bone marrow to obtain a concentrated source of stem cells, progenitor cells, growth factors, and cytokines. These biological components play a crucial role in tissue repair, regeneration, and healing. BMAC has become increasingly popular in orthopedics, sports medicine, pain management, and regenerative treatments due to its ability to support the b

Discover the scientific criteria to consider when choosing the best PRP kit. Evaluate PRP systems in terms of platelet concentration, Buffy Coat isolation, leukocyte profile, and clinical performance.